Disease Risk Factors Identified Through Shared Genetic Architecture and Electronic Medical Records.
Genome-wide association studies have identified genetic variants for thousands of diseases and traits. We evaluated the relationships between specific risk factors (for example, blood cholesterol level) and diseases on the basis of their shared genetic architecture in a comprehensive human disease–single-nucleotide polymorphism association database (VARIMED), analyzing the findings from 8962 published association studies. Similarity between...
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