Fibrosis underlies the loss of renal function in patients with chronic kidney disease (CKD) and in kidney transplant recipients with chronic allograftnephropathy (CAN). Here, we studied the effect of an intronic SNP in SHROOM3, which has previously been linked to CKD, on the development of CAN in a prospective cohort of renal allograft recipients. The presence of the rs17319721 allele at the SHROOM3 locus in the donor correlated with...

PURPOSE: The endoplasmic reticulum-associated degradation pathway is responsible for the translocation of misfolded proteins across the endoplasmic reticulum membrane into the cytosol for subsequent degradation by the proteasome. To define the phenotype associated with a novel inherited disorder of cytosolic endoplasmic reticulum-associated degradation pathway dysfunction, we studied a series of eight patients with deficiency of N-glycanase 1....

SEQC/MAQC-III Consortium. A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium. Nat Biotechnol. 2014 Sep;32(9):903-14. doi: 10.1038/nbt.2957. PMID:25150838  Dr. Rong Chen is in SEQC consortium. Here is the paper SEQC_NatBiotech. http://www.nature.com/nbt/journal/v32/n9/full/nbt.2957.html Abstract We present primary results from the Sequencing Quality Control (SEQC)...

Abstract:   Glicksberg B.S., Li L., Cheng W., Shameer K., Hakenberg J., Castellanos R., Meng M., Shi L., Shah H., Dudley J.T., Chen R., An integrated pipeline for multi-modal discovery of disease relationships.Pac Symp Biocomputp 2015