Likelihood Ratios for Genome Medicine.
Patients are beginning to present to healthcare providers with the results of high-throughput individualized genotyping, and interpreting these results in the context of the explosive growth of literature linking individual variants with disease may seem daunting. However, we suggest that results of a personal genomic analysis may be viewed as a panel of many tests for multiple diseases. By using well-established methods of evidence based medicine, these very many parallel tests may be combined using likelihood ratios to report a post-test probability of disease for use in patient assessment.
http://www.ncbi.nlm.nih.gov/pubmed/20497613
Morgan AA, Chen R, Butte AJ. Likelihood Ratios for Genome Medicine. Genome Med. 2010 May 17;2(5):30.